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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

《医学前沿（英文）》 2022年 第16卷 第5期   页码 723-735 doi: 10.1007/s11684-021-0905-y

摘要： Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. At present, no definite ALS biomarkers are available. In this study, exosomes from the plasma of patients with ALS and healthy controls were extracted, and differentially expressed exosomal proteins were compared. Among them, the expression of exosomal coronin-1a (CORO1A) was 5.3-fold higher than that in the controls. CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice. CORO1A was also overexpressed in NSC-34 motor neuron-like cells, and apoptosis, oxidative stress, and autophagic protein expression were evaluated. CORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy, and hindered the formation of autolysosomes. Moreover, CORO1A activated Ca2+-dependent phosphatase calcineurin, thereby blocking the fusion of autophagosomes and lysosomes. The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes. In conclusion, the role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease onset and progression by blocking autophagic flux. Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

关键词： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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Giant renal angiomyolipoma with tuberous sclerosis complex

Ouyan SHI PhD, Guodong XU BM, Chunxiang WANG BM,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 495-498 doi: 10.1007/s11684-009-0068-8

摘要： Though rare, angiomyolipomas (AMLs) are the most common mesenchymal tumors of kidney. In general, AMLs can always be associated with two conditions affecting other organ systems: tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis. This article presents a case of renal AML occurring in a 14-year-old girl with a definite diagnosis of TSC. She had been diagnosed with TSC at the age of three, and a schedule for close observation was disobeyed. At this time, she underwent a series of examinations: physical examination, ultrasonography, angiography, computed tomography (CT), and magnetic resonance imaging (MRI) scans. The physical examination showed adenoma sebaceum in a butterfly paranasal distribution, and a mass was palpated in the left upper quadrant. There were no neurological deficits. Imaging studies (including ultrasonography, angiography, CT, and MRI) of the abdomen showed a large heterogeneous mass arising from the left kidney. Partial nephrectomy was performed. The pathological diagnosis was hemorrhagic renal AML. No recurrence was found in the three-year follow-up. We concluded that schedule of close observation on patients with TSC should be strictly abided by for the high morbidity of AMLs. The specific risks of renal AMLs are spontaneous hemorrhage and rupture. Treatment options for AMLs include conservative and interventional (total/partial nephrectomy, cryoptherapy, and embolization) treatments.

关键词： renal angiomyolipoma     tuberous sclerosis complex     hemorrhage    

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Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

《医学前沿（英文）》 2021年 第15卷 第2期   页码 232-251 doi: 10.1007/s11684-020-0797-2

摘要： In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their role in non-cancerous pathological conditions remains in its infancy resulting in much confusion. Our objectives in this review are to address some recent advances in MDSC research in order to minimize such confusion and to provide an insight into their function in the context of other diseases. The following topics will be specifically focused upon: (1) definition and characterization of MDSCs; (2) whether all MDSC populations consist of immature cells; (3) technical issues in MDSC isolation, estimation and characterization; (4) the origin of MDSCs and their anatomical distribution in health and disease; (5) mediators of MDSC expansion and accumulation; (6) factors that determine the expansion of one MDSC population over the other; (7) the Yin and Yang roles of MDSCs. Moreover, the functions of MDSCs will be addressed throughout the text.

关键词： non-human primates (rhesus macaques)     myeloid-derived pro-inflammatory cells (MDPCs)     autoimmune disorders     alloimmune responses     pregnancy     mature MDSCs     multiple sclerosis     Yin-Yang law of MDSCs    

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Association of gene variants with juvenile amyotrophic lateral sclerosis

《医学前沿（英文）》 doi: 10.1007/s11684-023-1005-y

摘要： Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons, and it demonstrates high clinical heterogeneity and complex genetic architecture. A variation within TRMT2B (c.1356G>T; p.K452N) was identified to be associated with ALS in a family comprising two patients with juvenile ALS (JALS). Two missense variations and one splicing variation were identified in 10 patients with ALS in a cohort with 910 patients with ALS, and three more variants were identified in a public ALS database including 3317 patients with ALS. A decreased number of mitochondria, swollen mitochondria, lower expression of ND1, decreased mitochondrial complex I activities, lower mitochondrial aerobic respiration, and a high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and TRMT2B interfering HEK293 cells. Further, TRMT2B variations overexpression cells also displayed decreased ND1. In conclusion, a novel JALS-associated gene called TRMT2B was identified, thus broadening the clinical and genetic spectrum of ALS.

关键词： TRMT2B     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen species    

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An assessment of surrogate fuel using Bayesian multiple kernel learning model in sight of sooting tendency

《能源前沿（英文）》 2022年 第16卷 第2期   页码 277-291 doi: 10.1007/s11708-021-0731-6

摘要： An integrated and systematic database of sooting tendency with more than 190 kinds of fuels was obtained through a series of experimental investigations. The laser-induced incandescence (LII) method was used to acquire the 2D distribution of soot volume fraction, and an apparatus-independent yield sooting index (YSI) was experimentally obtained. Based on the database, a novel predicting model of YSI values for surrogate fuels was proposed with the application of a machine learning method, named the Bayesian multiple kernel learning (BMKL) model. A high correlation coefficient (0.986) between measured YSIs and predicted values with the BMKL model was obtained, indicating that the BMKL model had a reliable and accurate predictive capacity for YSI values of surrogate fuels. The BMKL model provides an accurate and low-cost approach to assess surrogate performances of diesel, jet fuel, and biodiesel in terms of sooting tendency. Particularly, this model is one of the first attempts to predict the sooting tendencies of surrogate fuels that concurrently contain hydrocarbon and oxygenated components and shows a satisfying matching level. During surrogate formulation, the BMKL model can be used to shrink the surrogate candidate list in terms of sooting tendency and ensure the optimal surrogate has a satisfying matching level of soot behaviors. Due to the high accuracy and resolution of YSI prediction, the BMKL model is also capable of providing distinguishing information of sooting tendency for surrogate design.

关键词： sooting tendency     yield sooting index     Bayesian multiple kernel learning     surrogate assessment     surrogate formulation    

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Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

《医学前沿（英文）》 2008年 第2卷 第2期   页码 171-173 doi: 10.1007/s11684-008-0031-0

摘要： This study aimed to investigate the treatment outcomes of esophageal variceal bleeding (EVB) in China. A total of 1087 cases were collected from 19 hospitals in 16 large and medium sized cities across China between January 1st, 2005 and January 1st, 2006. There were 313 cases (29.0%) of mild (<400 mL), 494 cases (45.8%) of moderate (400–1500 mL) and 272 cases (25.2%) of severe (>1500 mL) bleeding. Successful hemostasis was achieved in 89.8% of cases. Seven hundred and eighty-five cases were treated by medication with a hemostasis rate of 91.8%. Seventy-one cases were treated using a Sengstaken-Blakemore tube with a hemostasis rate of 54.9%. Thirty-seven cases were treated with emergency endoscopic variceal ligation with a hemostasis rate of 83.8%. Seventy-seven cases were treated with endoscopic sclerotherapy with a hemostasis rate of 94.8%. Forty-three cases were treated with emergency surgical operation with a hemostasis rate of 95.3%. Sixty-six cases were treated with combined therapy with a hemostasis rate of 97.0%. There was a significant difference ( < 0.01) in the successful hemostasis rate between different treatments. The overall mortality was 10.1%, among which 6.6% was directly caused by bleeding. The multivariate logistic regression analysis shows that the severity of bleeding, treatment methods, liver dysfunction and activation of hepatitis were predictive factors for successful hemostasis. Most cases of EVB were mild and moderate in severity. The first-line treatment for EVB is medication. Emergency endoscopic intervention has not been widely available yet. The overall management outcome of EVB has been improved.

关键词： significant difference     predictive     medication     first-line treatment     bleeding    

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多天线非正交多址接入技术：综述 Regular Papers

Fei-yan TIAN, Xiao-ming CHEN

《信息与电子工程前沿（英文）》 2019年 第20卷 第12期   页码 1665-1697 doi: 10.1631/FITEE.1900405

摘要： 作为一种前沿的物理层技术，非正交多址接入技术允许多用户共享同一时空资源，因此增加了可接入用户数量，从而改善频谱效率。在第5代及未来无线通信网络中，非正交多址接入技术为实现大规模万物互联提供了可行方案。然而，严重的共道干扰和较高的实施复杂度阻碍了其在实际系统中的应用。为解决这些问题，多天线技术凭借其在空间自由度上的优势，已被广泛应用于非正交多址接入系统。本文针对多天线技术在非正交多址接入系统中各种各样的应用提供了一个全面综述，主要强调其在消除空间干扰和降低实施复杂度上的优势。特别地，详细调查了多天线技术在两用户、多用户、大规模连接和异构非正交多址接入系统中的应用。最后，预测了未来相关研究方向与挑战。

关键词： 非正交多址接入；多天线技术；B5G；物联网    

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Sequential degradation-based burn-in test with multiple periodic inspections

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 519-530 doi: 10.1007/s42524-021-0166-0

摘要： Burn-in has been proven effective in identifying and removing defective products before they are delivered to customers. Most existing burn-in models adopt a one-shot scheme, which may not be sufficient enough for identification. Borrowing the idea from sequential inspections for remaining useful life prediction and accelerated lifetime test, this study proposes a sequential degradation-based burn-in model with multiple periodic inspections. At each inspection epoch, the posterior probability that a product belongs to a normal one is updated with the inspected degradation level. Based on the degradation level and the updated posterior probability, a product can be disposed, put into field use, or kept in the test till the next inspection epoch. We cast the problem into a partially observed Markov decision process to minimize the expected total burn-in cost of a product, and derive some interesting structures of the optimal policy. Then, algorithms are provided to find the joint optimal inspection period and number of inspections in steps. A numerical study is also provided to illustrate the effectiveness of our proposed model.

关键词： burn-in     degradation     multiple inspections     Wiener process     partially observed Markov decision process    

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Sensitivity analysis of the deterioration of concrete strength in marine environment to multiple corrosive

《结构与土木工程前沿（英文）》 2023年 第17卷 第2期   页码 175-190 doi: 10.1007/s11709-021-0791-z

摘要： The corrosion degradation behavior of concrete materials plays a crucial role in the change of its mechanical properties under multi-ion interaction in the marine environment. In this study, the variation in the macro-physical and mechanical properties of concrete with corrosion time is investigated, and the source of micro-corrosion products under different salt solutions in seawater are analyzed. Regardless of the continuous hydration effect of concrete, the damage effects of various corrosive ions (Cl–, SO42−, and Mg2+, etc.) on the tensile and compressive strength of concrete are discussed based on measurement in different salt solutions. The sensitivity analysis method for concrete strength is used to quantitatively analyze the sensitivity of concrete strength to the effects of each ion in a multi-salt solution without considering the influence of continued hydration. The quantitative results indicate that the addition of Cl– can weaken the corrosion effect of SO42− by about 20%, while the addition of Mg2+ or Mg2+ and Cl– can strengthen it by 10%–20% during a 600-d corrosion process.

关键词： sensitivity analysis     concrete strength     corrosion deterioration     multi-ion interaction     marine environment    

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Group-based multiple pipe routing method for aero-engine focusing on parallel layout

《机械工程前沿（英文）》 2021年 第16卷 第4期   页码 798-813 doi: 10.1007/s11465-021-0645-3

摘要： External pipe routing for aero-engine in limited three-dimensional space is a typical nondeterministic polynomial hard problem, where the parallel layout of pipes plays an important role in improving the utilization of layout space, facilitating pipe assembly, and maintenance. This paper presents an automatic multiple pipe routing method for aero-engine that focuses on parallel layout. The compressed visibility graph construction algorithm is proposed first to determine rapidly the rough path and interference relationship of the pipes to be routed. Based on these rough paths, the information of pipe grouping and sequencing are obtained according to the difference degree and interference degree, respectively. Subsequently, a coevolutionary improved differential evolution algorithm, which adopts the coevolutionary strategy, is used to solve multiple pipe layout optimization problem. By using this algorithm, pipes in the same group share the layout space information with one another, and the optimal layout solution of pipes in this group can be obtained in the same evolutionary progress. Furthermore, to eliminate the minor angle deviation of parallel pipes that would cause assembly stress in actual assembly, an accurate parallelization processing method based on the simulated annealing algorithm is proposed. Finally, the simulation results on an aero-engine demonstrate the feasibility and effectiveness of the proposed method.

关键词： multiple pipe routing     optimization algorithm     aero-engine     pipe grouping     parallel layout    

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Surface accuracy optimization of mechanical parts with multiple circular holes for additive manufacturing

Jinghua XU, Hongsheng SHENG, Shuyou ZHANG, Jianrong TAN, Jinlian DENG

《机械工程前沿（英文）》 2021年 第16卷 第1期   页码 133-150 doi: 10.1007/s11465-020-0610-6

摘要： Surface accuracy directly affects the surface quality and performance of mechanical parts. Circular hole, especially spatial non-planar hole set is the typical feature and working surface of mechanical parts. Compared with traditional machining methods, additive manufacturing (AM) technology can decrease the surface accuracy errors of circular holes during fabrication. However, an accuracy error may still exist on the surface of circular holes fabricated by AM due to the influence of staircase effect. This study proposes a surface accuracy optimization approach for mechanical parts with multiple circular holes for AM based on triangular fuzzy number (TFN). First, the feature lines on the manifold mesh are extracted using the dihedral angle method and normal tensor voting to detect the circular holes. Second, the optimal AM part build orientation is determined using the genetic algorithm to optimize the surface accuracy of the circular holes by minimizing the weighted volumetric error of the part. Third, the corresponding weights of the circular holes are calculated with the TFN analytic hierarchy process in accordance with the surface accuracy requirements. Lastly, an improved adaptive slicing algorithm is utilized to reduce the entire build time while maintaining the forming surface accuracy of the circular holes using digital twins via virtual printing. The effectiveness of the proposed approach is experimentally validated using two mechanical models.

关键词： surface accuracy optimization     multiple circular holes     additive manufacturing (AM)     part build orientation     triangular fuzzy number (TFN)     digital twins    

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Concentrating aqueous hydrochloric acid by multiple-effect membrane distillation

Rongling LIU, Yingjie QIN, Xiaojun LI, Liqiang LIU

《化学科学与工程前沿（英文）》 2012年 第6卷 第3期   页码 311-321 doi: 10.1007/s11705-012-1207-3

摘要： Multiple-effect membrane distillation (MEMD) using a hollow fiber-based air-gap membrane distillation module was experimentally examined for concentrating dilute aqueous hydrochloric acid. The effects of the hot and cold feed-in temperatures, and the feed-in volumetric flow rates on the performance of the MEMD process were studied. The performance was evaluated using the performance ratio ( ), the average selectivity of water over HCl ( ) and the permeation flux ( ). Two types of porous fibers made from polypropylene were used to fabricate the MEMD modules. The experimental data indicated that hollow fibers with high porosity were preferred for the MEMD process. The , and all decreased as the feed concentration increased. When the feed concentration was below 12 wt-%, the was 6.0 – 9.6 and was 10 – 190. When the concentration of HCl reached 18 wt-%, the and were about 4.4 and 2.3, respectively. However, sharply decreased to around 1.0 when the feed was further concentrated. During an operational stability test that lasted for 30 days, the performance of the MEMD modules remained good.

关键词： multiple-effect membrane distillation     performance ratio     hydrochloric acid     recovery     stability    

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Impacts of solar multiple on the performance of direct steam generation solar power tower plant with

Yan LUO, Xiaoze DU, Lijun YANG, Chao XU, Muhammad AMJAD

《能源前沿（英文）》 2017年 第11卷 第4期   页码 461-471 doi: 10.1007/s11708-017-0503-5

摘要： Solar multiple (SM) and thermal storage capacity are two key design parameters for revealing the performance of direct steam generation (DSG) solar power tower plant. In the case of settled land area, SM and thermal storage capacity can be optimized to obtain the minimum levelized cost of electricity (LCOE) by adjusting the power generation output. Taking the dual-receiver DSG solar power tower plant with a given size of solar field equivalent electricity of 100 MW in Sevilla as a reference case, the minimum LCOE is 21.77 ￠/kWh with an SM of 1.7 and a thermal storage capacity of 3 h. Besides Sevilla, two other sites are also introduced to discuss the influence of annual DNI. When compared with the case of Sevilla, the minimum LCOE and optimal SM of the San Jose site change just slightly, while the minimum LCOE of the Bishop site decreases by 32.8% and the optimal SM is reduced to 1.3. The influence of the size of solar field equivalent electricity is studied as well. The minimum LCOE decreases with the size of solar field, while the optimal SM and thermal storage capacity still remain unchanged. In addition, the sensitivity of different investment in sub-system is investigated. In terms of optimal SM and thermal storage capacity, they can decrease with the cost of thermal storage system but increase with the cost of power generation unit.

关键词： direct steam generation     solar power tower     solar multiple     thermal energy storage capacity     levelized cost of electricity (LCOE)    

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Supplier selection and order splitting in multiple-sourcing inventory systems

WANG Guicong, JIANG Zhaoliang, LI Zhaoqian, LIU Wenping

《机械工程前沿（英文）》 2008年 第3卷 第1期   页码 23-27 doi: 10.1007/s11465-008-0016-3

摘要： Supplier selection and inventory control are critical decision processes in single-item multiple-supplier systems. An integer linear programming model is proposed to help managers determine the reorder level, choose the best suppliers, and place the optimum order quantities so that the total average inventory cost is minimum, and constraints of supplier ability, quality, and demand are considered. An algorithm combining the branch-bound algorithm and enumeration algorithm is developed to solve the problems. Application of the proposed model in an automobile industry shows that it is effective.

关键词： automobile industry     branch-bound algorithm     selection     single-item multiple-supplier     effective    

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A rank-based multiple-choice secretary algorithm for minimising microgrid operating cost under uncertainties

《能源前沿（英文）》 2023年 第17卷 第2期   页码 198-210 doi: 10.1007/s11708-023-0874-8

摘要： The increasing use of distributed energy resources changes the way to manage the electricity system. Unlike the traditional centralized powered utility, many homes and businesses with local electricity generators have established their own microgrids, which increases the use of renewable energy while introducing a new challenge to the management of the microgrid system from the mismatch and unknown of renewable energy generations, load demands, and dynamic electricity prices. To address this challenge, a rank-based multiple-choice secretary algorithm (RMSA) was proposed for microgrid management, to reduce the microgrid operating cost. Rather than relying on the complete information of future dynamic variables or accurate predictive approaches, a lightweight solution was used to make real-time decisions under uncertainties. The RMSA enables a microgrid to reduce the operating cost by determining the best electricity purchase timing for each task under dynamic pricing. Extensive experiments were conducted on real-world data sets to prove the efficacy of our solution in complex and divergent real-world scenarios.

关键词： energy management systems     demand response     scheduling under uncertainty     renewable energy sources     multiple-choice secretary algorithm    

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标题 作者 时间 类型 操作

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

期刊论文

Giant renal angiomyolipoma with tuberous sclerosis complex

Ouyan SHI PhD, Guodong XU BM, Chunxiang WANG BM,

期刊论文

Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

期刊论文

Association of gene variants with juvenile amyotrophic lateral sclerosis

期刊论文

An assessment of surrogate fuel using Bayesian multiple kernel learning model in sight of sooting tendency

期刊论文

Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

期刊论文

多天线非正交多址接入技术：综述

Fei-yan TIAN, Xiao-ming CHEN

期刊论文

Sequential degradation-based burn-in test with multiple periodic inspections

期刊论文

Sensitivity analysis of the deterioration of concrete strength in marine environment to multiple corrosive

期刊论文

Group-based multiple pipe routing method for aero-engine focusing on parallel layout

期刊论文

Surface accuracy optimization of mechanical parts with multiple circular holes for additive manufacturing

Jinghua XU, Hongsheng SHENG, Shuyou ZHANG, Jianrong TAN, Jinlian DENG

期刊论文

Concentrating aqueous hydrochloric acid by multiple-effect membrane distillation

Rongling LIU, Yingjie QIN, Xiaojun LI, Liqiang LIU

期刊论文

Impacts of solar multiple on the performance of direct steam generation solar power tower plant with

Yan LUO, Xiaoze DU, Lijun YANG, Chao XU, Muhammad AMJAD

期刊论文

Supplier selection and order splitting in multiple-sourcing inventory systems

WANG Guicong, JIANG Zhaoliang, LI Zhaoqian, LIU Wenping

期刊论文

A rank-based multiple-choice secretary algorithm for minimising microgrid operating cost under uncertainties

期刊论文